ArticleJournal of lipid and atherosclerosis2026
Association Between Lipid-Lowering Drug Use and Sarcopenia: Analysis of the Korea National Health and Nutrition Examination Survey.
Article in Journal of lipid and atherosclerosis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Beyond Fat Loss: Addressing the Sarcopenia Challenge of Incretin-Based Therapies.Diabetes & metabolism journal · 2026Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Lipid-lowering drugs are known to cause various muscle-related side effects; however, it remains unclear whether their use contributes to reduced muscle mass and sarcopenia. This study aimed to evaluate the association between the use of lipid-lowering drugs and both muscle mass and the prevalence of sarcopenia. Methods: We conducted a cross-sectional analysis using data from 18,668 adults aged ≥20 years from the Korea National Health and Nutrition Examination Survey 2008-2011. Sarcopenia was defined based on appendicular skeletal muscle mass (ASM), measured using dual-energy X-ray absorptiometry. The association between hyperlipidemia medication and the prevalence of sarcopenia was estimated using complex samples logistic regression. Results: Patients with hyperlipidemia exhibited lower ASM/wt than those without hyperlipidemia. After adjusting for potential confounders, including current lipid profiles, ASM/wt did not differ significantly between the general population and hyperlipidemic patients not receiving medication. However, individuals taking lipid-lowering drugs demonstrated significantly lower ASM/wt. This trend was mirrored in sarcopenia prevalence, with odds ratios of 2.89 (95% confidence interval [CI], 1.95-4.28) in men and 1.68 (95% CI, 1.26-2.24) in women ( Conclusion: These results suggest that the use of lipid-lowering drugs may contribute to a decrease in muscle mass and a higher risk of sarcopenia. However, the generalizability of these results is limited, and further longitudinal studies are required to confirm the association.
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