ReviewJournal of thoracic disease2026
2025 report on advances in thoracic aortic disease research.
Review in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Sex-Specific Growth Rates of Ascending Thoracic Aortic Aneurysms in Non-Syndromic Patients: A Systematic Review.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review summarizes advances in thoracic aortic disease research published in 2025, with literature retrieved from 2,829 articles via PubMed searches, focusing on risk prediction, pathogenesis, and treatment strategies. In risk prediction, key advances include: biomechanical validation of ascending aortic length (AAL) as a stable morphological predictor; the relationship between clonal hematopoiesis and thoracic aortic aneurysm (TAA) linked to Janus kinase 2 (JAK2) (V617F) mutation variant allele frequency (VAF); the iAorta artificial intelligence (AI) system achieving acute aortic syndrome (AAS) detection on non-contrast computed tomography (CT); and sex differences revealed by the DisSEXion study demonstrating significantly higher type A dissection incidence in women. Additional advances include cardiac magnetic resonance (CMR)-derived three-dimensional (3D) distensibility and displacement mapping, high biaxiality ratio analysis, integration of phenotypic age acceleration with genetic risk, reduced plasma cartilage oligomeric matrix protein (COMP) levels as a warning biomarker, gene-specific differences in hereditary thoracic aortic disease (HTAD), air pollution as an environmental risk factor, and causal association between remnant cholesterol and aortic disease. In pathogenesis, the hexosamine biosynthetic pathway-integrated stress response (HBP-ISR) axis provides a common therapeutic target for both hereditary and sporadic disease; piezo type mechanosensitive ion channel component (PIEZO)1 regulates transforming growth factor (TGF)-β signaling with the Yoda1 agonist showing therapeutic potential; Calpain-2-mediated endothelial focal adhesion disruption plays a critical role in dissection; CX3CR1+ macrophages can be targeted by C-C chemokine receptor (CCR)2 antagonist, which mitigates aneurysm progression; the cyclin-dependent kinase-like (CDKL)1-ciliary function association introduces ciliary biology into aortic pathophysiology; and developmental origin-dependent susceptibility differences among smooth muscle cells (SMCs) are identified. In treatment, the frozen elephant trunk (FET) strategy shows excellent long-term survival and functional recovery. The Society of Thoracic Surgeons (STS) risk model improves preoperative assessment. Analysis clarifies high mortality risks associated with coronary and mesenteric malperfusion. PERSEVERE study confirms favorable aortic remodeling with Ascyrus Medical Dissection Stent (AMDS) hybrid prosthesis. Importantly, research emphasizes the critical role of hospital rescue capability and regionalized aortic care networks, with evidence supporting efficient inter-hospital transfer systems to improve outcomes. Advances in compliant stent-grafts and total endovascular aortic arch repair techniques expand treatment options for high-risk patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.