ArticleJournal of thoracic disease2026
Efficacy and safety of time-of-day infusion of pemetrexed plus platinum for patients with advanced non-small cell lung cancer: a retrospective cohort study.
Article in Journal of thoracic disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Efficacy and safety of time-of-day infusion of pemetrexed plus platinum for patients with advanced non-small cell lung cancer: a retrospective cohort study.Journal of thoracic disease · 2026Article
- Opportunities for Precision Dosing of Cytotoxic Drugs in Non-Small Cell Lung Cancer: Bridging the Gap in Precision Medicine.Clinical pharmacokinetics · 2025Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Retrospective studies indicate that morning chemotherapy enhances efficacy and reduces side effects in non-small cell lung cancer (NSCLC). However, the role of infusion timing for pemetrexed plus platinum (AP) chronotherapy remains unclear. This study evaluates the impact of AP administration time on efficacy and safety in advanced NSCLC. Methods: We retrospectively analyzed 132 advanced NSCLC patients receiving AP chemotherapy at Guangdong Second Provincial General Hospital from 2018 to 2023. Based on previous research, patients were grouped into morning (AM; infusion before 2:00 PM, n=58) and afternoon (PM; n=74) groups. Treatment response was evaluated using the Response Evaluation Criteria in Solid Tumors Criteria V.1.1. The primary endpoint was progression-free survival (PFS), with safety profile serving as the secondary endpoint. All adverse events (AEs) were identified and graded according to the National Cancer Institute-Common Terminology Criteria for Adverse Events version 5.0. Results: The AM group showed significantly longer PFS than the PM group (24.0 Conclusions: AP treatment administered in the morning may enhance PFS in advanced NSCLC. This suggests that chrono-chemotherapy (CCT) could potentially enhance the efficacy of individualized chemotherapy in advanced NSCLC.
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