Evidence map›Paper›PMID 41660426›Full record

ArticleFrontiers in cellular and infection microbiology2026

SSTDhunter: a curated gene database for investigating androgen producing potential in microbiota species.

Shaojing Wang, Yifan Yang, Li Lei, Rongxin Wan, Zhaoying Su, Yan Liu, Huiqin Tang, Guoying Hu, Changlin Li, Changying Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shaojing WangTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Yifan YangCheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Li LeiTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Rongxin WanTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Zhaoying SuCollection Management Department, Natural History Museum of China, Beijin, China.
Yan LiuTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Huiqin TangTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Guoying HuTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Changlin LiTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Changying LiTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Jinhuan MengTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.
Kuo YangTianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Androgens are critical for the growth of prostate cells, as well as prostate tumor cells. For prostate cancer patients under Androgen Deprivation Therapy (ADT) such as castration treatment, investigating the potential for androgen production by gut microbes is crucial. In microbe species, the side chain cleavage activity of steroid-17, 20-desmolase (SSTD) is responsible for 11-oxy-androgens production by biotransformation from cortisol, as well as from other endogenous steroids and pharmaceutical glucocorticoids. The side-chain cleavage product of prednisone could significantly promote the proliferation of prostate cancer cells. The SSTD is a complex formed by N-terminal and C-terminal transketolases encoded by

Indexed as

AndrogensDatabases, GeneticMicrobiotaBiocurationComputational BiologyHumansAndrogensandrogensgut microbiomeprostate cancerSSTDhunter databasesteroid-17,20-desmolase

Identifiers

PMID41660426
PMCPMC12876203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.