Evidence map›Paper›PMID 41660411›Full record

ArticlePathogens & immunity2026

Gastrointestinal Mucosal Disruptions During ART-Treated SIV

Sydney M Nemphos, Hannah C Green, James E Prusak, Sallie L Fell, Cecily Midkiff, Avelina Rodgers, Jillian Perret, Kelly Goff, Jordyn Miller, Megan Varnado and 15 more

Abstract read
In one paragraph

Article in Pathogens & immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sydney M NemphosDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Hannah C GreenDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
James E PrusakDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Sallie L FellDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Cecily MidkiffDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, Louisiana.
Avelina RodgersDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, Louisiana.
Jillian PerretDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, Louisiana.
Kelly GoffDivision of Microbiology, Tulane National Biomedical Research Center, Covington, Louisiana.
Jordyn MillerDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Megan VarnadoDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Kaitlin DidierDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Natalie ValenciaDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Matilda J MoströmDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Coty TatumDivision of Microbiology, Tulane National Biomedical Research Center, Covington, Louisiana.
Mary B BarnesDivision of Microbiology, Tulane National Biomedical Research Center, Covington, Louisiana.
Clara E KrzykwaDivision of Microbiology, Tulane National Biomedical Research Center, Covington, Louisiana.
Lori A RoweDivision of Microbiology, Tulane National Biomedical Research Center, Covington, Louisiana.
Carolina AllersDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Brooke GraspergeDivision of Veterinary Medicine, Tulane National Biomedical Research Center, Covington, Louisiana.
Kristina De ParisDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina.
Nicholas J ManessDivision of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana.
Amitinder KaurDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.
Berlin Londono-RenteriaDepartment of Tropical Medicine and Infectious Disease, Tulane University Celia Scott Weatherhead School of Public Health and Tropical Medicine, New Orleans, Louisiana.
Robert V BlairDivision of Comparative Pathology, Tulane National Biomedical Research Center, Covington, Louisiana.
Jennifer A ManuzakDivision of Immunology, Tulane National Biomedical Research Center, Covington, Louisiana.

Funding

Tulane NPRC SPF Sheltered Outdoor Enclosure ExpansionP51OD011104 · OD · TULANE UNIVERSITY OF LOUISIANA · PI L Lee HAMM · 2012 to 2026
$142.4M
Viral Testing CoreU42OD024282 · OD · TULANE UNIVERSITY OF LOUISIANA · PI KASI E RUSSELL-LODRIGUE · 2017 to 2026
$25.7M
Viral Testing Core - Maintenance of an SPF Macaque Breeding Colony for AIDS ResearchU42OD010568 · OD · TULANE UNIVERSITY OF LOUISIANA · PI Eric J. Vallender · 2013 to 2026
$21.7M
Neutrophil-driven mucosal dysfunction in SIV/malaria co-infectionR21OD031435 · OD · TULANE UNIVERSITY OF LOUISIANA · PI MANUZAK, JENNIFER · 2021 to 2022
$680k
Automated Staining Platform for Immunohistochemistry and In Situ HybridizationS10OD030347 · OD · TULANE UNIVERSITY OF LOUISIANA · PI BLAIR, ROBERT · 2021 to 2021
$228k
NIH HHS P51 OD011104NIH HHS R21 OD031435NIH HHS S10 OD030347NIH HHS U42 OD010568NIH HHS U42 OD024282
6 · The paper itself

Abstract

Background: Human immunodeficiency virus (HIV) and Methods: Adult male rhesus macaques (RMs; n=6) were inoculated with SIVmac239, initiated ART at week 8 post-SIV infection (p.i.), were inoculated with Results: We observed significant CCR5+ CD4+ T cell decline in the periphery, colon, and duodenum following SIV infection. Neutrophil frequencies were unchanged throughout ART-treated SIV/ Conclusions:

Indexed as

Disease Models (Animal)Gastrointestinal TractHIVHIV Co-infectionInfectious DiseasesInnate ImmunityMalariaNeutrophil Extracellular TrapsNeutrophilsPlasmodiumSimian Immunodeficiency Virus

Identifiers

PMID41660411
PMCPMC12880234

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.