Evidence map›Paper›PMID 41660407›Full record

Observational studyTremor and other hyperkinetic movements (New York, N.Y.)2026

Intention Tremor Severity Trajectory: Results from a Prospective Longitudinal Study of Essential Tremor.

Elan D Louis, Diane S Berry, Nora C Hernandez, Ethan Wainman, Ericka D Carter, Vibhash D Sharma

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Tremor and other hyperkinetic movements (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Longitudinal Intention Tremor Trajectories in Essential Tremor: A Comment.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elan D LouisDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-2062-362X
Diane S BerryDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0003-4867-0663
Nora C HernandezDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-7038-1492
Ethan WainmanDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Ericka D CarterDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Vibhash D SharmaDepartment of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0001-5543-0305

Funding

Clinical Pathological Study of Cognitive Impairment in Essential TremorR01NS086736 · NINDS · YALE UNIVERSITY · PI COSENTINO, STEPHANIE ANN, LOUIS, ELAN D · 2014 to 2023
$8.1M
NIH HHS R01NS086736
6 · The paper itself

Abstract

Introduction: Patients with essential tremor (ET) may exhibit intention tremor (IT), a sign of cerebellar dysfunction. The prevalence of this sign has been established in cross-sectional studies. To date, however, there have been no cohort studies, re-assessing ET cases prospectively, to determine whether the severity of IT increases over time. The fundamental question is whether IT is progressive in ET. Methods: 90 cases enrolled in a prospective, longitudinal study of elders with ET. IT was assessed in each arm during the finger-nose-finger maneuver (10 repetitions per arm) and scored by a movement disorders neurologist on a 3-item scale - 0 (absent), 0.5 (probable), or 1 (definite), with the IT score (sum of IT in both arms) ranging from 0 - 2. Data from four evaluations every 18 months (T1 - T4) over a 4.5-year period were analyzed. Results: A one-way repeated measures analysis of variance revealed a time effect for IT, indicating significant variance across time in this variable. Paired sample t-tests indicated that the mean IT score at T4 was greater than those at T1, T2 and T3. There was heterogeneity in the sample, with the T4 score being greater than the T1 score in 46 (51.1%) of 90, but not all individuals. Conclusion: The cerebellar sign, IT, progressively worsened over time in ET. To our knowledge, this is the first demonstration that

Indexed as

Essential TremorNeurologic ExaminationSeverity of Illness IndexTremorAgedAged, 80 and overCerebellar DiseasesCerebellumDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesSymptom AssessmentCerebellarCerebellumClinicalEssential tremorIntention tremor

Identifiers

PMID41660407
PMCPMC12879989

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.