Evidence map›Paper›PMID 41660401›Full record

ArticleFrontiers in pediatrics2025

Association between birthweight discordance and extrauterine growth restriction among preterm twins: a national multi-center study in China.

Qian Chen, Bijun Shi, Lizi Lin, Danfang Lu, Jiayi Zhang, Shuhua Ren, Kang Huang, Wei Shen, Zhifeng Chen, Jin Liu and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Qian Chen *Department of Child Healthcare, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Bijun Shi *Department of Child Healthcare, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Lizi LinJoint International Research Laboratory of Environment and Health, Ministry of Education, Guangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk Assessment, Department of Occupational and Environmental Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China.
Danfang LuDepartment of Pediatrics, Peking University Third Hospital, Beijing, China.
Jiayi ZhangThe First Clinical Medical College of Kunming Medical University, Kunming Medical University, Kunming, Yunnan, China.
Shuhua RenDepartment of Neonatology, Sichuan Jinxin Xinan Women & Children's Hospital, Chengdu, Sichuan, China.
Kang HuangDepartment of Neonatology, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Wei ShenDepartment of Neonatology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Zhifeng ChenDepartment of Neonatology, The Tenth Affiliated Hospital of Southern Medical University, Dongguan, Guangdong, China.
Jin LiuDepartment of Neonatology, The First Affiliated Hospital of Shaoyang University, Shaoyang, Hunan, China.
Chunming YouDepartment of Neonatology, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China.
Guifang LiDepartment of Neonatology, Cangzhou People's Hospital, Cangzhou, Hebei, China.
Hong JiangDepartment of Neonatology, Affiliated Hospital of Yan an University, Yan' an, Shanxi, China.
Hongping RaoDepartment of Neonatology, Huizhou Central People's Hospital, Huizhou, Guangdong, China.
Jianwu QiuDepartment of Neonatology, The Affiliated Yue Bei People's Hospital of Shantou University Medical College, Shaoguan, Guangdong, China.
Xian WeiDepartment of Neonatology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan, Hubei, China.
Yayu ZhangDepartment of Neonatology, The Affiliated Hospital of Inner Mongolia Medical University, Hohot, Inner Mongolia, China.
Xiaobo LinDepartment of Neonatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Haiyan JiangDepartment of Neonatology, Affiliated Hospital of Guizhou Medical University, Baotou, Inner Mongolia, China.
Shasha HanDepartment of Neonatology and Pediatrics, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China.
Fan WangDepartment of Neonatology, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Weixing ZhangDepartment of Neonatology, Xinxiang Central Hospital, Xinxiang, Henan, China.
Xiufang YangDepartment of Neonatology, Neonatology Department, Zhongshan City People's Hospital, Zhongshan, Guangdong, China.
Yitong WangDepartment of Neonatology, The Binhaiwan Central Hospital of Dongguan, Dongguan, Guangzhou, China.
Niyang LinDepartment of Neonatology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
Xiaohua TanDepartment of Child Healthcare, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Qiliang CuiDepartment of Neonatology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: This multicenter study investigated the association between birthweight discordance (BWD) and extrauterine growth restriction (EUGR) in preterm twins, and evaluated the modifying role of small for gestational age (SGA). Methods: Data from 2,496 infants (1,248 twin pairs) admitted to 22 Chinese NICUs (2018-2020) were analyzed. BWD was calculated as the percentage difference in birthweight between larger and smaller twins, categorized into four groups (≤15%, 15%-20%, 20%-25%, >25%). EUGR was defined as discharge weight below the 10th percentile for corrected gestational age and sex (Fenton's chart). A generalized linear mixed model was employed to analyze the association between BWD and EUGR. Modification analysis was performed to assess the effect of SGA on this association. Results: BWD of >25% was associated with a significantly increased risk of EUGR compared to BWD ≤15% (adjusted OR = 1.59, 95% CI: 1.05-2.41). Stratified analysis revealed a consistent association in SGA infants (OR = 1.38, 95% CI: 1.30-1.47). Conclusion: Findings highlight BWD as a critical risk factor for EUGR, particularly in SGA twins. This association suggests that future research should investigate whether tailored monitoring and nutritional interventions in NICUs could help mitigate these growth disparities.

Indexed as

birthweight discordanceextrauterine growth restrictionNICUsmall gestation agetwin

Identifiers

PMID41660401
PMCPMC12876194

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