ArticleBioactive materials2026
A polymeric triple-enzyme nanoparticle by light activatable crosslinking for cascade catalytic therapy of osteosarcoma.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Chemotactic Gold Nanozyme-Powered Flasklike Pentosan Nanobots for Tumor-Specific Drug Delivery.Advanced healthcare materials · 2026Article
- Bacterial outer membrane vesicle-based biomimetic nitric oxide-releasing nanogenerator for boosting antitumor efficiency of enzyme dynamic therapy via augmented autophagy and immunoactivation.Journal of nanobiotechnology · 2026Article
- CCR2-overexpressing mesenchymal stromal cell-derived extracellular vesicles loaded with MPA ameliorate lupus nephritis.Journal of nanobiotechnology · 2026Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Multi-enzymatic cascade reactions play fundamental roles in biosynthesis, energetic metabolism, cell signaling, proliferation and apoptosis in living cells. Such reactions have been proposed for cancer therapy via overproducing reactive oxygen species, depleting nutrients for tumor starvation, or remodeling immunosuppressive microenvironment, however, co-delivery of multiple enzymes with optimal cascade catalytic activity remains challenging. Here, we propose a polymer nanoparticle loaded with glucose oxidase (GOx), lactate oxidase (LOx), and chloroperoxidase (CPO) for synergistic cancer catalytic therapy. The enzymes were complexed with O-nitrobenzyl-modified ε-polylysine via ionic and hydrophobic interactions, followed by light-activated crosslinking to prepare serum-stable and pH-responsive protein nanoparticles. The GOx and LOx in the nanoparticle efficiently deplete glucose and lactate, generating excessive hydrogen peroxide, while CPO further catalyze hydrogen peroxide in the presence of chloride ions to produce singlet oxygen (
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