ArticleSurgical neurology international2026
Effectiveness of the combination of bovine scaffold and autologous calvarial bone dust in burr hole defect closure post-osteoplasty.
Article in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
Background: Craniotomy involves creating multiple burr holes followed by the opening of a bone flap. After the intracranial procedure, the bone flap is replaced (osteoplasty), but burr hole defects remain and may lead to scalp depressions over time. This study evaluates the effectiveness of using a graft combination of bovine scaffold material and autologous calvarial bone dust for burr hole defect closure in calvarial osteoplasty. Methods: The scaffold was derived from the epiphysis of bovine cancellous femur bone, prepared by the tissue bank of Dr. Soetomo General Hospital, and adjusted to fit burr hole defects. Four patients underwent grafting with this combination during osteoplasty. All patients were followed up and evaluated at least 1 year after graft placement. Clinical assessment focused on scalp depressions, while head computed tomography (CT) scans were used to evaluate bone integration between the calvarial bone and the graft. Results: Among four patients, one showed scalp depression at the graft site, while the other three had no visible indentations. CT scans demonstrated that the three cases without scalp depression have intact grafts with cortical thickening in some areas. The single case with depression exhibited graft resorption and lytic bone changes. Importantly, no signs of graft rejection or allergic reactions were observed in any patient. Conclusion: This study suggests that the combination of bovine scaffold material and autologous calvarial bone dust in burr hole defect closure during calvarial osteoplasty can prevent scalp depression in the defect area.
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