Evidence map›Paper›PMID 41660311›Full record

ReviewSurgical neurology international2026

Radiation-induced meningiomas: A systematic review and meta-analysis of 927 meningiomas.

Neil D Almeida, Sarthak Sinha, Mengyu Fang, Daniel Sullivan, Julia Rupp, Harshini Cheruvu, Rohil Shekher, Victor Goulenko, Venkatesh Madhugiri, Tyler V Schrand and 2 more

Abstract readReview
In one paragraph

Review in Surgical neurology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Neil D AlmeidaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Sarthak SinhaDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Mengyu FangDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Daniel SullivanDepartment of Radiation Medicine, Jacob School of Medicine and Biomedical Sciences, Buffalo, New York, United States.
Julia RuppDepartment of Radiation Medicine, Jacob School of Medicine and Biomedical Sciences, Buffalo, New York, United States.
Harshini CheruvuDepartment of Statistics and Data Science, Cornell University, Ithaca, United States.
Rohil ShekherDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Victor GoulenkoDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Venkatesh MadhugiriDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.
Tyler V SchrandDepartment of Biochemistry and Molecular Biology, Tulane University School of Medicine, New Orleans, New Orleans, Louisiana, United States.
Michael T MilanoDepartment of Radiation Oncology, University of Rochester Medical Center, Rochester, United States.
Dheerendra PrasadDepartment of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Meningiomas are the most common intracranial tumor. Ionizing radiation has been implicated in the pathogenesis of radiation-induced meningiomas (RIM). Compared to spontaneous meningiomas, RIM are a clinically aggressive entity and are more likely to develop clinical and radiologic progression. Methods: Systematic searches of Medline, Embase, and Cochrane Central Register of Controlled Trials were performed. Pooled data were used to calculate rates of survival, tumor control, and adverse events. Results: Thirty studies met the final inclusion criterion within this meta-analysis. In total, these studies reported on 927 RIMs in 825 patients. Patients were grouped by whether they received cranial radiotherapy ([CRT]; Conclusion: High- and low-dose cranial radiation therapy can differentially influence the latency and grade of RIM, with higher dose CRT associated with earlier onset and more atypical tumors RIM screening may be warranted in individuals with an early exposure to cranial radiation given the increased risk of developing secondary neoplasms. These findings support structured long-term magnetic resonance imaging surveillance for survivors of childhood cranial irradiation, with risk adapted follow-up protocols to enable earlier detection and management.

Indexed as

MeningiomaRadiation-induced meningiomaRadiotherapy

Identifiers

PMID41660311
PMCPMC12875240

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.