ReviewiScience2026
Self-assembly of plant-derived bioactive nanostructures in traditional Chinese medicine.
Review in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Self-assembled structures as a material basis for indirect pharmacology in Traditional Chinese Medicine.Chinese medicine · 2026Review
- Development trends and translational opportunities in self-assembled herbal bioactive materials research.Discover nano · 2026Review
- Engineering Multi-Scale Transdermal Delivery Systems for Atopic Dermatitis: Emerging Insights from the Gut-Skin Axis.International journal of nanomedicine · 2026Review
- Programmable Self-Assembly of Traditional Chinese Medicine (TCM) Monomers: From Molecular Mechanisms to Multifunctional Nanomedicine.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional Chinese medicine (TCM) relies on plant-derived compounds to achieve therapeutic effects through multi-component and multi-level regulation. Increasing evidence indicates that many bioactive constituents in TCM can spontaneously self-assemble into nanoscale aggregates under aqueous or physiological conditions. This review summarizes current knowledge on the self-assembly behavior of representative plant-derived small molecules, including terpenoids, polyphenols, and alkaloids, and discusses their structural features, non-covalent interaction mechanisms, and experimental characterization strategies. We highlight how self-assembled nanostructures-such as nanoparticles, micelles, and hydrogels-exhibit improved solubility, stability, bioavailability, and delivery performance compared with free molecules. These assembly behaviors are closely coupled to molecular architecture and environmental responsiveness. By integrating supramolecular chemistry with traditional herbal pharmacology, this work provides a conceptual framework for understanding the material basis of TCM efficacy and supports the rational development of plant-derived nanomedicines with translational potential.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.