ArticleiScience2026
Genomic biomarkers of immunotherapy plus chemotherapy in patients with advanced NSCLC: Insights from the phase 3 ORIENT-11 study.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Exploring the mechanism by which triphenyl phosphate promotes malignant phenotypes in bladder and kidney cancer through MMP9 based on bioinformatics analysis and experimental validation.Clinical and experimental medicine · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To optimize patient selection for first-line immune-checkpoint inhibitor plus chemotherapy (ICI-Chemo) in advanced non-small cell lung cancer (NSCLC), we developed a 9-gene Immune-Chemotherapy Prediction Score (ICPscore) from the phase 3 ORIENT-11 trial. A high ICPscore identified patients with markedly superior progression-free and overall survival from ICI-Chemo versus chemotherapy alone, whereas low-scorers derived minimal benefit, outperforming existing biomarkers such as PD-L1. Its predictive value for immunotherapy efficacy was further validated in the OAK (NSCLC) and IMvigor210 (metastatic urothelial cancer) cohorts. Multi-cohort and single-cell analyses linked a high ICPscore to an immune-active tumor microenvironment characterized by myeloid cell activation, thus providing a biological rationale for its enhanced performance and positioning it as a robust tool for treatment personalization.
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