Evidence map›Paper›PMID 41660266›Full record

ArticleiScience2026

TREM2 and APOE are dispensable for microglial clearance of dying neurons revealed by

Anupama Rai, Eyiyemisi C Damisah, Robert A Hill, Lei Tong, Jaime Grutzendler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Anupama RaiDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Eyiyemisi C DamisahDepartment of Neurosurgery, Yale School of Medicine, New Haven, CT, USA.
Robert A HillDepartment of Biological Sciences, Dartmouth College, Hanover, NH, USA.
Lei TongDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.
Jaime GrutzendlerDepartment of Neurology, Yale School of Medicine, New Haven, CT, USA.

Funding

Yale Alzheimer Disease Research CenterP30AG066508 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2020 to 2026
$30.2M
Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Molecular probes to image and target the neurovascular unit in health and diseaseR01NS115544 · NINDS · YALE UNIVERSITY · PI GRUTZENDLER, JAIME · 2020 to 2024
$3.1M
Biological basis of post-delirium cognitive declineRF1AG058257 · NIA · YALE UNIVERSITY · PI GRUTZENDLER, JAIME · 2017 to 2017
$2.9M
Therapeutic targeting of angiophagy to achieve microvascular recanalizationR01NS111961 · NINDS · YALE UNIVERSITY · PI GRUTZENDLER, JAIME · 2019 to 2023
$2.3M
Uncovering mechanisms of myelin formation and regeneration in the live brainR00NS099469 · NINDS · DARTMOUTH COLLEGE · PI HILL, ROBERT · 2018 to 2020
$746k
NCATS NIH HHS KL2 TR001862NIA NIH HHS P30 AG066508NIA NIH HHS RF1 AG058257NINDS NIH HHS R00 NS099469NINDS NIH HHS R01 NS111961NINDS NIH HHS R01 NS115544
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Cell biologyMolecular biologyNeuroscience

Identifiers

PMID41660266
PMCPMC12877822

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.