Evidence map›Paper›PMID 41660259›Full record

ArticleiScience2026

Modulation of striatal cAMP levels: A key pathway in the treatment of hyperkinetic movement disorders.

Ruiyi Yuan, Emmanuel Roze, Mohamed Doulazmi, Caroline Dubacq, Sophie Longueville, Marine Delmas, Boutheyna Khelaifia, Julia Micaux, Yuki Nakamura, Marco Romanato and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Distinct Brain Drivers and Shared Cerebello-Cortical Input in ADCY5 and SGCE Hyperkinetic Movements.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Psychiatric Disorders and Apathy in Mixed Movement Disorders Linked to ADCY5 (MxMD-ADCY5).Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ruiyi YuanSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Emmanuel RozeSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Mohamed DoulazmiSorbonne University, INSERM, CNRS, Institute of Biology Paris-Seine, Paris, France.
Caroline DubacqSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Sophie LonguevilleSorbonne University, Fer à Moulin Institute, INSERM, Paris, France.
Marine DelmasSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Boutheyna KhelaifiaSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Julia MicauxSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Yuki NakamuraSorbonne University, Fer à Moulin Institute, INSERM, Paris, France.
Marco RomanatoSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Clément TarranoSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Noël ZahrAP-HP, Pitié-Salpêtrière Hospital, Department of Pharmacology, Paris, France.
Assunta PelosiSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Marie VidailhetSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Jean-Antoine GiraultSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Aurélie MéneretSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Denis HervéSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.
Louise-Laure MarianiSorbonne University, Paris Brain Institute, INSERM, CNRS, Paris, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperkinetic movement disorders, like dystonia, chorea, myoclonus, dyskinesia, and tremor, can be extremely disabling, impairing quality of life. Our translational approach in humans and mice investigates the link between cyclic AMP (cAMP) signaling pathway alterations in striatal neurons and hyperkinetic movement disorders.

Indexed as

Molecular biologyNeurosciencePharmacology

Identifiers

PMID41660259
PMCPMC12876317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.