Evidence map›Paper›PMID 41660247›Full record

ArticleiScience2026

Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production.

Zixian Wang, Yanxi Chen, Yongqi Feng, Gaoyu Zu, Wenxu Wang, Limiao Liang, Xinyu Liu, Yuhang Mei, Jiaxuan Yang, Tian Wang and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Zixian WangState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.
Yanxi ChenDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Yongqi FengState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China.
Gaoyu ZuDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Wenxu WangInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Limiao LiangState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.
Xinyu LiuDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Yuhang MeiDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Jiaxuan YangHanGene Biotech, Xiaoshan Innovation Polis, Hangzhou, Zhejiang 31200, China.
Tian WangMOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Mengqi LiuMOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Linxi JiangMOE Key Laboratory of Metabolism and Molecular Medicine and Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences&Fudan University Shanghai Cancer Center, Shanghai Medical College of Fudan University, Shanghai 200032, China.
Russell G SnellApplied Translational Genetics Group, School of Biological Sciences, the University of Auckland, Auckland, New Zealand.
Blake HighetDepartment of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.
Maurice CurtisDepartment of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand.
Liang ChenDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Shi-Bin LiInstitute for Translational Brain Research, State Key Laboratory of Medical Neurobiology, MOE Frontiers Center for Brain Science, Fudan University, Shanghai, China.
Jinsong WuGlioma Surgery Division, Neurological Surgery Department of Huashan Hospital, Fudan University, Shanghai 200040, China.
Menghan ZhangState Key Laboratory of Genetics and Development of Complex Phenotypes, Center for Evolutionary Biology, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, School of Life Sciences, Fudan University, Shanghai, China.
Wensheng LiDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
Gong-Hong WeiState Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences&Peking Union Medical College, Suzhou 215123, China.
Linya YouDepartment of Human Anatomy&Histoembryology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human speech and language depend on hemispheric specialization across cortical regions and cortico-striatal circuits. We profiled 125 human cortical samples from 13 Brodmann areas (BAs), bilaterally, across five donors to generate a hemisphere-resolved transcriptomic atlas and quantify region-specific lateralization. Integrating genome-wide association signals for speech-, language-, and reading-related traits with brain

Indexed as

AudiologyGenomicsNeuroscienceSensory neuroscience

Identifiers

PMID41660247
PMCPMC12876320

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.