Evidence map›Paper›PMID 41660065›Full record

ArticleStructural heart : the journal of the Heart Team2026

Ischemic vs. Nonischemic Cardiomyopathy in TAVR for Moderate Aortic Stenosis: A TAVR UNLOAD Sub Analysis.

Philipp von Stein, Henning Guthoff, Björn Redfors, Julia B Thompson, Ernest Spitzer, Philippe Pibarot, Jeroen J Bax, Jan G P Tijssen, Michael L Chuang, Yukari Kobayashi and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Structural heart : the journal of the Heart Team, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Philipp von SteinDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany.
Henning GuthoffDepartment of Cardiology, Heart Center, Faculty of Medicine, University of Cologne, Cologne, Germany.
Björn RedforsCardiovascular Research Foundation, New York, New York, USA.
Julia B ThompsonCardiovascular Research Foundation, New York, New York, USA.
Ernest SpitzerDepartment of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
Philippe PibarotDepartment of Medicine, Québec Heart and Lung Institute, Laval University, Québec City, Québec, Canada.
Jeroen J BaxDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.
Jan G P TijssenAcademic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Michael L ChuangCardiovascular Research Foundation, New York, New York, USA.
Yukari KobayashiCardiovascular Research Foundation, New York, New York, USA.
Arsalan Abu-MuchCardiovascular Research Foundation, New York, New York, USA.
Nicole CristellCardiovascular Research Foundation, New York, New York, USA.
Alexandra PopmaCardiovascular Research Foundation, New York, New York, USA.
David J CohenCardiovascular Research Foundation, New York, New York, USA.
Sammy ElmariahDivision of Cardiology, Department of Medicine, University of San Francisco, San Francisco, California, USA.
Martin B LeonCardiovascular Research Foundation, New York, New York, USA.
Nicolas M Van MieghemDepartment of Cardiology, Thoraxcenter, Cardiovascular Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.
TAVR UNLOAD trial study investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

•This exploratory analysis of the Transcatheter Aortic Valve Replacement to UNload the Left ventricle in patients with ADvanced heart failure trial did not identify evidence of a differential treatment effect of transcatheter aortic valve replacement compared to clinical aortic stenosis surveillance according to cardiomyopathy etiology (ischemic versus nonischemic) in patients with heart failure with reduced ejection fraction and moderate aortic stenosis.•The study was underpowered to definitively exclude a potential modifying effect of cardiomyopathy etiology, and any differential treatment response may require longer follow-up to become apparent.

Indexed as

Aortic stenosisAScardiomyopathyICMIschemicModerateTAVRTranscatheter aortic valve replacement

Identifiers

PMID41660065
PMCPMC12874415

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.