ArticleFrontiers in neurology2025
PREVENT: Towards the prevention of intracranial vessel perforations during mechanical thrombectomy - protocol for a multicenter registry study.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06394180 (PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PeRforation EVents During ENdovascular Therapy for Acute Ischemic Stroke (PREVENT) - Registry
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10 authors.
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Abstract
Rationale: The increasing use of thrombectomy for acute ischemic stroke highlights the need to better understand its complications. Vessel perforation leading to active intracranial bleeding is a severe complication associated with a poor outcome and a mortality rate of approximately 50%. The etiology and risk factors for this severe complication remain largely unknown, and there is limited evidence to guide decision-making regarding endovascular hemostatic strategies and the continuation of thrombectomy after perforation. Design: The Perforation EVents during ENdovascular Therapy for acute ischemic stroke (PREVENT) Registry is an international, multicenter, prospective, and retrospective study, collecting data on vessel perforations during thrombectomy. The registry aims to include 500 cases of vessel perforation and 500 matched controls without perforation. The collected data will consist of both tabulated data and periprocedural imaging, which is to be analyzed centrally by an imaging core laboratory. Data will be analyzed using a case-control method, employing both univariate and multivariate statistical analyses. Objectives: The primary objectives of this study are to (1) identify risk factors for vessel perforation, (2) explore the underlying pathophysiology, (3) develop a classification system for vessel perforations, (4) compare different hemostatic treatment strategies, (5) evaluate the impact of continuing versus aborting thrombectomy after perforation, and (6) propose a safety-optimized thrombectomy technique. Discussion: Given the frequency and hyperacute nature of vessel perforations, a prospective randomized study is not feasible. This large, international registry provides a robust approach to collecting real-world evidence, reducing bias through multicenter data collection and case matching. The findings may help improve clinical decision-making and enhance patient safety during thrombectomy procedures. Clinical trial registration: ClinicalTrials.gov, identifier NCT06394180.
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