Evidence map›Paper›PMID 41659947›Full record

ArticleClinical case reports2026

STAT3-Mutated Hyper-IgE Syndrome With Retroperitoneal Abscess in Adolescence.

Hiroaki Sugiyama, Yousuke Higuchi, Shintaro Fujiwara, Koki Aya, Wataru Mukai, Takafumi Goto

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hiroaki SugiyamaDepartment of Pediatrics NHO Okayama Medical Center Okayama Japan.
Yousuke HiguchiDepartment of Pediatrics NHO Okayama Medical Center Okayama Japan.ORCID https://orcid.org/0000-0001-5253-6569
Shintaro FujiwaraDepartment of Pediatrics NHO Okayama Medical Center Okayama Japan.ORCID https://orcid.org/0000-0002-9340-2484
Koki AyaDepartment of Pediatric Surgery NHO Okayama Medical Center Okayama Japan.
Wataru MukaiDepartment of Pediatric Surgery NHO Okayama Medical Center Okayama Japan.
Takafumi GotoDepartment of Pediatric Surgery NHO Okayama Medical Center Okayama Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder characterized by eczema, recurrent staphylococcal infections, and significantly elevated serum IgE levels. An 18-year-old female presented with acute abdominal pain and was diagnosed with a retroperitoneal abscess. She had a history of recurrent skin abscesses, otitis media, and eczema since infancy, skeletal fractures, and retained primary teeth. Laboratory findings showed a serum IgE level above 20,150 U/L and a CRP of 180.30 mg/L. Methicillin-sensitive

Indexed as

hyper‐IgE syndromemethicillin‐sensitive Staphylococcus aureusprimary immunodeficiency disorderretroperitoneal abscessSTAT3 variant

Identifiers

PMID41659947
PMCPMC12872590

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.