Evidence map›Paper›PMID 41659917›Full record

ArticleTrauma surgery & acute care open2026

Is early venous thromboembolism prophylaxis safe and effective in trauma patients requiring urgent neurosurgical interventions: analysis of the prospective multicenter CLOTT study.

Yutung Wu, John Peter Gruen, Kazuhide Matsushima, Morgan Schellenberg, Kenji Inaba, Ernest E Moore, Angela Sauaia, Mary Margaret Knudson, Matthew J Martin, CLOTT Study Group

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Trauma surgery & acute care open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Yutung WuDepartment of Trauma and Emergency Surgery, Chang Gung Memorial Hospital Linkou, Taoyuan, Taiwan.ORCID https://orcid.org/0000-0002-2145-8710
John Peter GruenDepartment of Neurosurgery, Los Angeles General Medical Center, Los Angeles, California, USA.
Kazuhide MatsushimaDivision of Trauma, Emergency Surgery, and Surgical Critical Care, Los Angeles General Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-9625-5363
Morgan SchellenbergDivision of Trauma, Emergency Surgery, and Surgical Critical Care, Los Angeles General Medical Center, Los Angeles, California, USA.
Kenji InabaDivision of Trauma, Emergency Surgery, and Surgical Critical Care, Los Angeles General Medical Center, Los Angeles, California, USA.
Ernest E MooreErnest E Moore Shock Trauma Center, Denver Health Medical Center, Denver, Colorado, USA.
Angela SauaiaColorado School of Public Health, University of Colorado Denver Anschutz Medical Campus, Aurora, Colorado, USA.
Mary Margaret KnudsonDepartment of Surgery, University of California San Francisco, San Francisco, California, USA.
Matthew J MartinDivision of Trauma, Emergency Surgery, and Surgical Critical Care, Los Angeles General Medical Center, Los Angeles, California, USA.
CLOTT Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Timely initiation of venous thromboembolism prophylaxis (VTEp) has been known to decrease venous thromboembolism (VTE after trauma; however, early VTEp in patients undergoing neurosurgical interventions (NSIs) is controversial with conflicting reports in the literature from retrospective studies. We aimed to evaluate the safety and outcomes of early VTEp in this high-risk cohort. Methods: The study was a secondary analysis from the prospective multicenter Consortium of Leaders in the Study of Traumatic Thromboembolism database. Traumatic brain injury (TBI) patients receiving NSI were included. Patients were divided into early (≤72 hours) and late (>72 hours) VTEp groups. Mortality, VTE, deep vein thrombosis (DVT), pulmonary embolism, and bleeding adverse events including progression of intracranial hemorrhage (pICH) were compared. Results: Among the total 238 patients, 233 (97.9%) underwent craniotomy or craniectomy, and 140 (58.8%) received early VTEp. Patients with a head Abbreviated Injury Scale score of 5 and craniectomy were more likely to delay VTEp (>72 hours) (all p<0.05). Compared with late VTEp, early VTEp exhibited lower rates of VTE (10.7% vs 16.3%, p=0.28) and DVT (8.6% vs 15.3%, p=0.16), though without achieving statistical significance. Through generalized estimating equation and competing risk analysis, early VTEp did not demonstrate a significant decrease of VTE risk (OR) 0.74, 95% CI 0.33 to 1.67; HR 0.90, 95% CI 0.45 to 1.84), whereas the risk of adverse bleeding events (OR 0.79, 95% CI 0.24 to 2.57) or pICH (OR 1.10, 95% CI 0.30 to 4.03) did not increase with early VTEp either. Conclusion: Early VTEp is not significantly associated with reduced rates of VTE or DVT in patients with severe TBI requiring emergent NSI, but it also does not increase the risk of adverse bleeding event or pICH. Level of evidence: Level IV; therapeutic/care management.

Indexed as

Brain Injuries, TraumaticneurosurgeryThromboembolismVenous thromboembolism

Identifiers

PMID41659917
PMCPMC12878300

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.