ArticleFrontiers in immunology2026
Case Report: Complete remission of Guillain-Barré syndrome in neuropsychiatric lupus with telitacicept.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Neuropsychiatric systemic lupus erythematosus (NPSLE) manifesting as Guillain-Barré syndrome (GBS) is exceptionally rare, with only 28 documented cases in medical literature, and current biological therapies show limited efficacy. We report a 34-year-old woman who presented with progressive quadriparesis, bilateral ptosis, and facial palsy developing over one month. Laboratory investigations revealed marked B-cell dysregulation with elevated immunoglobulin G (24.30 g/L, normal 7-16), positive antinuclear antibodies (1:320), anti-double-stranded DNA antibodies (128 IU/ml, normal <20), anti-ribosomal P antibodies (450 AU/ml, normal <20), and hypocomplementemia (C3 1.10 g/L, C4 0.28 g/L). Cerebrospinal fluid analysis showed cytoalbuminologic dissociation (protein 1314 mg/L, cells 1×10
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