Evidence map›Paper›PMID 41659846›Full record

ArticleFrontiers in immunology2026

Alessandro Testori, Antonella Mulas, Mara Marongiu, Valeria Orrù, Monia Lobina, Maria Grazia Piras, Erika Lutzu, Nicolò Curreli, Cristina Politi, Marco Mobrici and 8 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Alessandro TestoriIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Antonella MulasIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Mara MarongiuIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Valeria OrrùIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Monia LobinaIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Maria Grazia PirasIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Erika LutzuIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Nicolò CurreliIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
Cristina PolitiIstituto di Fisiologia Clinica (IFC) - Consiglio Nazionale delle Ricerche (CNR), Reggio Calabria, Italy.
Marco MobriciIstituto di Fisiologia Clinica (IFC) - Consiglio Nazionale delle Ricerche (CNR), Reggio Calabria, Italy.
Giorgio IervasiIstituto di Fisiologia Clinica (IFC) - Consiglio Nazionale delle Ricerche (CNR), Pisa, Italy.
Daniela CordaIstituto degli Endotipi in Oncologia, Metabolismo e Immunologia "G. Salvatore" (IEOMI), - Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy.
Mario De FeliceIstituto degli Endotipi in Oncologia, Metabolismo e Immunologia "G. Salvatore" (IEOMI), - Consiglio Nazionale delle Ricerche (CNR), Napoli, Italy.
Alessandra TestaIstituto di Fisiologia Clinica (IFC) - Consiglio Nazionale delle Ricerche (CNR), Reggio Calabria, Italy.
Marcella DevotoIstituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Maristella Steri *Istituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Cagliari, Italy.
Edoardo Fiorillo *Istituto di Ricerca Genetica e Biomedica (IRGB) - Consiglio Nazionale delle Ricerche (CNR), Lanusei, Italy.
SerGenCovid-19 Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The immunoglobulin level following vaccination against SARS-CoV-2 results from a multifaceted immunological process involving cells and molecules that determine its efficacy and protect us against severe infection outcomes. The observed heterogeneity in the immune response to vaccination is partly attributable to host genetic factors; however, this genetic contribution has only been partially explored. Methods: To elucidate the mechanisms underlying the antibody response elicited by the Pfizer-BioNTech vaccine, we conducted a genome-wide association study on anti-spike immunoglobulin G levels measured in 1,968 Italian individuals who received two doses of the vaccine, selected from a larger cohort of 7,169 volunteers characterized for 8 million genetic variants. Sex, age, body mass index, smoking habit, and time elapsed between vaccine administration and blood draw were accounted as covariates in the linear regression model. Results: We identified a novel signal of association on chromosome 3 in the intronic region of the Conclusions: These findings support a role for

Indexed as

BNT162 VaccineChemokinesCOVID-19GranulocytesMyeloid-Derived Suppressor CellsSARS-CoV-2AdultAgedAntibodies, ViralFemaleGenome-Wide Association StudyHumansImmunoglobulin GMaleMiddle AgedPolymorphism, Single NucleotideAntibodies, ViralBNT162 VaccineChemokinesImmunoglobulin GBNT162b2CMTM8GWASHLAMDSC (myeloid-derived suppressor cells)

Identifiers

PMID41659846
PMCPMC12875989

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.