ArticleFrontiers in cellular and infection microbiology2025
Comparison of the effects of clear aligners and fixed appliances on the oral microbiota and reactive oxygen species: a prospective study.
Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07506993 (Molar-Specific Inflammatory Biomarkers in Adolescents Using Clear Aligners With and Without Attachments), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molar-Specific Inflammatory Biomarkers in Adolescents Using Clear Aligners With and Without Attachments
Who cites it
2 citing papers in PubMed.
- The Relationship Between Orthodontic Malocclusion Severity and Periodontal Clinical and Biochemical Parameters in Adolescents: A Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2026Article
- The impact of clear aligners therapy on dental caries: a systematic review.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to compare the effects of clear aligners (CA) and fixed appliances (FA) on periodontal indices, oral microbiota, and oxidative stress markers. Potential associations between microbial changes, oxidative stress, and periodontal health were also explored. Methods: Twenty-four orthodontic patients matched at baseline were randomly allocated to the CA (n = 12) and FA (n = 12) groups. Saliva, supragingival plaque, and gingival crevicular fluid (GCF) were collected at baseline (T0), 3 months (T1), and 6 months (T2). Periodontal indices, including plaque index (PI), gingival index (GI), probing depth (PD), bleeding on probing (BOP) were recorded. Microbial composition was assessed via 16S rDNA sequencing. 8-Hydroxy-2'-deoxyguanosine (8-OHdG, a stable biomarker of oxidative DNA damage reflecting ROS levels) in saliva and GCF was quantified using double-antibody sandwich ELISA. Associations were analyzed using Spearman correlation. Results: PI was significantly higher in the FA group than CA group at T1 ( Conclusions: Fixed appliances were associated with enrichment of pathogenic taxa, elevated oxidative stress markers, and worse periodontal indices, potentially linked to higher periodontitis risk. Clear aligners showed less microbial disruption and health-associated taxa enrichment. The
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Registered trials
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