Evidence map›Paper›PMID 41659804›Full record

ArticleFrontiers in nutrition2025

Impact of chitosan oligosaccharide on microbiota-metabolite-immune axis in natural aging.

Wei Liu, Pengcheng Shi, Yunyu Xiao, Xi Yang, Baoming Tian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wei LiuZhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Pengcheng ShiZhejiang Provincial Key Laboratory of Agricultural Microbiomics, Institute of Plant Protection and Microbiology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Yunyu XiaoZhejiang Golden Shell Pharmaceutical Co., Ltd, Yuhuan, China.
Xi YangFuyao University of Science and Technology, Fuzhou, Fujian, China.
Baoming TianCollege of Food Science and Technology, Zhejiang University of Technology, Huzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Natural aging involves an imbalance in gut bacteria, changes in metabolism, and mild ongoing inflammation. The integrated impact of chitosan oligosaccharide (COS) on microbiota-metabolite-immune interactions in a physiological (non-accelerated) aging context remains unclear. In this study, male C57BL/6J mice (young control; aged vehicle; aged +COS from 10 to 18 months) underwent longitudinal assessment including 16S rRNA profiling, untargeted serum metabolomics, multiplex cytokine measurement, and colonic p53 and p21 immunohistochemistry. The results showed that COS was associated with restructuring of gut community composition, with reduced Firmicutes (67.07% to 32.93%) and increased

Indexed as

chitooligosaccharidegut microbiotainflammationMuribaculaceaenatural agingpropionate metabolism

Identifiers

PMID41659804
PMCPMC12876160

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.