ArticleBioactive materials2026
Assembly of bioinspired multifunctional microspheres for enhanced alveolar bone regeneration.
Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Regeneration of the alveolar bone remains a major clinical challenge due to the complex oral microenvironment and the need for coordinated restoration of multiple tissue types. To overcome these hurdles, biomaterials designed for periodontal regeneration must meet a rigorous set of criteria, including excellent injectability, mechanical stability, selective cell repopulation, and strong osteoinductive capacity. In this study, we developed a bioinspired, multifunctional microsphere system that fulfills these requirements. The system is injectable, mechanically robust, selectively binds bone marrow-derived stem cells (BMSCs), and exhibits potent osteoinductivity. These multifunctional properties were achieved by UV-assembling nanofibrous hollow microspheres (NFH-MS), conjugating the BMSC-specific E7 peptide to the nanofibrous shell, and encapsulating a bone-forming peptide (BFP) within the hollow core. UV-assembly enhanced the scaffold's mechanical integrity, generated interconnected macropores to support cell infiltration, and promoted intercellular communication. Notably, it significantly upregulated Connexin 43 and N-cadherin-mediated junctions, further facilitating cellular interactions. In synergy with E7 and BFP, the UV-assembled NFH-MS scaffold markedly improved BMSC adhesion, osteogenic differentiation, and biomineralization. This bioinspired multifunctional NFH-MS platform demonstrated superior alveolar bone regeneration in a rat fenestration defect model, offering a promising and minimally invasive strategy for periodontal tissue engineering.
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