Evidence map›Paper›PMID 41659723›Full record

ReviewFrontiers in oncology2026

Brain metastases from non-small cell lung cancer: molecular subtypes and emerging CNS-directed precision therapies.

Mehek Sharma, Anvay Shah, Kimberly A Rivera-Caraballo, Girindra Raval, Balveen Kaur, Gerald C Wallace

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mehek SharmaMedical College of Georgia at Augusta University, Augusta, GA, United States.
Anvay ShahMedical College of Georgia at Augusta University, Augusta, GA, United States.
Kimberly A Rivera-CaraballoMedical College of Georgia at Augusta University, Augusta, GA, United States.
Girindra RavalMedical College of Georgia at Augusta University, Augusta, GA, United States.
Balveen KaurMedical College of Georgia at Augusta University, Augusta, GA, United States.
Gerald C WallaceMedical College of Georgia at Augusta University, Augusta, GA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small-cell lung cancer (NSCLC) is a leading cause of morbidity and mortality globally, due in large part to the development of NSCLC-associated brain metastases (L-BM). Upon initial presentation, 11-26% of patients with NSCLC will have L-BM, while half of patients with NSCLC will develop L-BM over the course of their disease. The emergence of PD-1/PD-L1 immunotherapy and targeted therapies for

Indexed as

BBB penetrationbrain metastasesmolecular biomarkersnon-small cell lung cancerpatient-centered outcomestargeted therapies

Identifiers

PMID41659723
PMCPMC12872532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.