Evidence map›Paper›PMID 41659669›Full record

ArticlebioRxiv : the preprint server for biology2026

Spatial mapping of RNA turnover kinetics and regulatory landscapes of mRNA stability in the mammalian brain.

Qi Qiu, Hongjie Zhang, Zijie Xia, William Gao, Julie Leu, Dongming Liang, Ying Li, Yijing Su, Emily Feierman, Erin Van Horn and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qi QiuDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Hongjie ZhangDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Zijie XiaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
William GaoDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Julie LeuDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Dongming LiangDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Ying LiDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Yijing SuDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Emily FeiermanDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Erin Van HornDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Guo-Li MingDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Erica KorbDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Hongjun SongDepartment of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Zhaolan ZhouDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.
Hao WuDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104.ORCID 0000-0003-4395-6929

Funding

The Penn Human Precision Pain Center (HPPC): Discovery and Functional Evaluation of Human Primary Somatosensory Neuron Types at Normal and Chronic Pain ConditionsU19NS135528 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Mingyao Li, Wenqin Luo · 2023 to 2026
$11.2M
Defining causal roles of genomic variants on gene regulatory networks with spatiotemporally-resolved single-cell multiomicsU01HG012047 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI HONGJUN SONG, Hao Wu · 2021 to 2026
$7.1M
Underpinnings of corneal innervation: anatomical, molecular, and functional studies of corneal sensory afferents in physiologic and pathologic statesU01EY034681 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Vivian Lee, Wenqin Luo · 2022 to 2026
$5.5M
NEI NIH HHS U01 EY034681NHGRI NIH HHS U01 HG012047NINDS NIH HHS U19 NS135528
6 · The paper itself

Abstract

Spatial and activity-dependent gene regulation in the mammalian brain requires coordinated control of RNA synthesis and degradation

Identifiers

PMID41659669
PMCPMC12874000

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.