Evidence map›Paper›PMID 41659667›Full record

ArticlebioRxiv : the preprint server for biology2026

Altered thalamo-prefrontal synchrony dynamics during spatial working memory task performance in a SETD1A loss-of-function mouse model of schizophrenia predisposition.

Sofiya Hupalo, David A Kupferschmidt, Ako Ikegami, Mia Railing, Maxym V Myroshnychenko, Gabriel Loewinger, Francisco Pereira, Joseph A Gogos, Joshua A Gordon

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Sofiya HupaloIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
David A KupferschmidtIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Ako IkegamiIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Mia RailingIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Maxym V MyroshnychenkoIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Gabriel LoewingerMachine Learning Team, National Institute of Mental Health, Bethesda, Maryland.
Francisco PereiraMachine Learning Team, National Institute of Mental Health, Bethesda, Maryland.
Joseph A GogosZuckerman Institute, Columbia University, New York, New York.
Joshua A GordonIntegrative Neuroscience Section, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.

Funding

Probing the neural circuit basis of normal and disease-relevant cognitive function in miceZIANS003168 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GORDON, JOSHUA · 2018 to 2025
$11.8M
Hippocampal, Thalamic, and Prefrontal Oscillatory Mechanisms Underlying Working MemoryFI2GM133387 · NIGMS · U.S. NATIONAL INST/NEURO/DS/STROKE · PI HUPALO, SOFIYA · 2019 to 2019
–
Intramural NIH HHS ZIA NS003168NIGMS NIH HHS FI2 GM133387
6 · The paper itself

Abstract

Schizophrenia is associated with profound working memory deficits, for which there are no approved treatments. Rare heterozygous null mutations in

Identifiers

PMID41659667
PMCPMC12873781

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.