Evidence map›Paper›PMID 41659662›Full record

ArticlebioRxiv : the preprint server for biology2026

Antigen presentation requirements for effective cDC1-based cancer immunotherapy.

Josué E Pineda, Tomoyuki Minowa, Li Shen, Yifan Zhou, Allison M Dyevoich, Bhakti Patel, Sarah M Schneider, Sunita Keshari, Akata Saha, Morgan N Riba and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Josué E PinedaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8132-1804
Tomoyuki MinowaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8353-036X
Li ShenDepartment of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-8427-9448
Yifan ZhouDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-0975-1479
Allison M DyevoichDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-4106-0435
Bhakti PatelDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-8090-0193
Sarah M SchneiderDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7027-7978
Sunita KeshariDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-4889-8430
Akata SahaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-3125-2871
Morgan N RibaDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-3572-1484
Jing WangDepartment of Bioinformatics and Computational Biology, Division of Discovery Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-5398-0802
Stephanie S WatowichDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-1969-659X
Matthew M GubinDepartment of Immunology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0001-7443-2752

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI DIANE BODURKA · 1985 to 2026
$290.8M
Bhlhe40 Regulation of T Cell Function During Cancer ImmunotherapyR01CA282027 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Matthew M. Gubin · 2024 to 2026
$3.0M
Regulation and function of nonlymphoid organ CD103+ dendritic cellsR56AI109294 · NIAID · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WATOWICH, STEPHANIE S · 2021 to 2021
$481k
Evaluating Antigen Spread After cDC1 VaccinationF30CA290816 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Morgan Nicole Riba · 2025 to 2026
$76k
NCI NIH HHS F30 CA290816NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA282027NIAID NIH HHS R56 AI109294
6 · The paper itself

Abstract

Type 1 conventional dendritic cells (cDC1s) are important for generating and sustaining antitumor immunity. Accordingly, the abundance of cDC1s in human tumors correlates with improved outcomes in cancer. Capitalizing on this role, we previously demonstrated that vaccination with

Indexed as

Antigen presentationcDC1Dendritic cell vaccinesMHC class IMHC class II

Identifiers

PMID41659662
PMCPMC12874039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.