Evidence map›Paper›PMID 41659648›Full record

ArticlebioRxiv : the preprint server for biology2026

REGULATION OF COLONIC MACROPHAGES AND TYPE-17 AND REGULATORY T CELLS IN DSS-COLITIS BY IBD-ASSOCIATED TRANSCRIPTION FACTOR, CREM.

Shelby L Schenck, Md Jashim Uddin, Christopher F Pastore, Audrey C Brown, William A Petri

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shelby L SchenckMicrobiology, Immunology, and Cancer Biology Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.ORCID 0009-0005-4075-5939
Md Jashim UddinDivision of Infectious Disease and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0002-2466-7198
Christopher F PastoreMicrobiology, Immunology, and Cancer Biology Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.ORCID 0000-0002-1002-6138
Audrey C BrownDivision of Infectious Disease and International Health, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.ORCID 0000-0001-5572-0396
William A PetriMicrobiology, Immunology, and Cancer Biology Graduate Program, University of Virginia Health System, Charlottesville, VA 22908, USA.

Funding

Role of CREM in Amebic Colitis and Inflammatory Bowel DiseaseR37AI026649 · NIAID · UNIVERSITY OF VIRGINIA · PI William A Petri · 2018 to 2026
$5.0M
NIAID NIH HHS R37 AI026649
6 · The paper itself

Abstract

Background: Recent genome wide association studies (GWAS) performed by our laboratory identified polymorphisms at the locus containing the gene, cAMP-responsive element modulator (CREM), that influence Methods: Mice were generated with either a tamoxifen-inducible global deletion or an intestinal epithelial cell (IEC)-specific deletion of Results: Tamoxifen-inducible global deletion of Conclusions: Inducible global deletion of

Identifiers

PMID41659648
PMCPMC12873985

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.