Evidence map›Paper›PMID 41659643›Full record

ArticlebioRxiv : the preprint server for biology2026

Multi-omics Differential Inference for Functional Interpretation (MoDIFI): A Statistical Framework to Prioritize Cell Lines for Neurodevelopmental Variants.

Arvinden Vr, Grace Tzun-Wen Shaw, Juana Manuel, Timothy L Mosbruger, Hillary Heins, Jeffrey K Ng, Haedong Kim, Tristan J Hayeck, Tychele N Turner

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Arvinden VrDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-1008-1348
Grace Tzun-Wen ShawDivision of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0003-4393-3655
Juana ManuelDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0000-0023-1245
Timothy L MosbrugerDivision of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-9254-6531
Hillary HeinsDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0009-0009-5648-4239
Jeffrey K NgDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-6134-1832
Haedong KimDivision of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0002-8804-3763
Tristan J HayeckDivision of Genomic Diagnostics, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia, Philadelphia, PA.ORCID 0000-0001-6898-6177
Tychele N TurnerDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0001-8246-6477

Funding

Noncoding mutations in neurodevelopmental disordersR01MH126933 · NIMH · WASHINGTON UNIVERSITY · PI Tychele Naomi Turner · 2022 to 2026
$3.6M
NIMH NIH HHS R01 MH126933
6 · The paper itself

Abstract

Noncoding variants contribute to neurodevelopmental disorders (NDDs), but their regulatory effects are often cell-type specific, making it difficult to choose an

Indexed as

ATACBayes FactorBayesianCell lineHi-Cneurodevelopmental disordernoncodingRNAstatistical framework

Identifiers

PMID41659643
PMCPMC12873933

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.