Evidence map›Paper›PMID 41659612›Full record

ArticlebioRxiv : the preprint server for biology2026

Methionine metabolism and the NOP2 methyltransferase are essential for MYC-Driven liver tumorigenesis.

Sensen Lin, Charles Berdan, Moriah Sandy, Xinjun Lu, Vijay Ramani, Daniel K Nomura, Xin Chen, Joyce Lee, Andrei Goga

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sensen LinDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
Charles BerdanDepartment of Chemistry, College of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Moriah SandyDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Xinjun LuDepartment of Pancreato-Biliary Surgery and Liver Transplantation Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Vijay RamaniGladstone Institute for Data Science and Biotechnology, Gladstone Institutes, San Francisco, CA, USA.
Daniel K NomuraDepartment of Chemistry, College of Chemistry, University of California, Berkeley, Berkeley, CA, USA.
Xin ChenDepartment of Bioengineering and Therapeutic Sciences and Liver Center, University of California, San Francisco, CA, USA.
Joyce LeeDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.
Andrei GogaDepartment of Cell and Tissue Biology, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9127-0986

Funding

Uncovering Mechanisms of Regulation and Dependency on Fatty Acid Oxidation in MYC-Driven TumorsR01CA223817 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GOGA, ANDREI · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA223817
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) represents the third leading cause of cancer-related death worldwide and has been increasing in developed nations.

Indexed as

Liver cancermetabolismmethionine dependenceMYCNOP2RAS

Identifiers

PMID41659612
PMCPMC12873830

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.