Evidence map›Paper›PMID 41659605›Full record

ArticlebioRxiv : the preprint server for biology2026

Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis.

Andrea B Alber, George Kwong, Vishal K Gupta, Porter E Dooley, Jill R Patel, Pushpinder S Bawa, Kasey Minakin, Dakota Jones, Diya Gopal, Huan Souza and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Andrea B AlberCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
George KwongCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Vishal K GuptaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Porter E DooleyCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Jill R PatelCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Pushpinder S BawaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Kasey MinakinCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Dakota JonesCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Diya GopalCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Huan SouzaDepartment of Physics, Boston University, Boston, MA 02215, USA.
Maria YampolskayaDepartment of Physics, Boston University, Boston, MA 02215, USA.
Eitan VilkerCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Chandani SenDepartment of Pediatrics, David Geffen School of Medicine, UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, University of California, Los Angeles, CA 90095, USA.
Ansley S ConcholaDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Pankaj MehtaDepartment of Physics, Boston University, Boston, MA 02215, USA.ORCID 0000-0003-1290-5897
Brigitte N GompertsDepartment of Pediatrics, David Geffen School of Medicine, UCLA Children's Discovery and Innovation Institute, Mattel Children's Hospital, University of California, Los Angeles, CA 90095, USA.
Tristan FrumDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Jason R SpenceDepartment of Internal Medicine, Division of Gastroenterology and Hepatology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Konstantinos-Dionysios AlysandratosCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.
Darrell N KottonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA 02118, USA.

Funding

Patient-specific iPSCs to model and treat the inception of pulmonary fibrosisP01HL170952 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANDREW A WILSON · 2024 to 2026
$11.4M
Derivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5M
Supplement to a Hox-Wnt-Sox signaling axis regulates lung development, patterning and branchingR01HL119215 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2013 to 2021
$4.2M
MODELING EMERGENT BEHAVIORS IN SYSTEMS BIOLOGY: A BIOLOGICAL PHYSICS APPROACHR35GM119461 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Pankaj Mehta · 2016 to 2026
$3.6M
Developing a patient-specific organoid model of pulmonary fibrosis using iPSCsU01HL152976 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2021 to 2024
$2.5M
Functional interrogation of a novel SCGB3A2+/SFTPB+ cell in the human airwayR01HL166139 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason Spence · 2023 to 2026
$2.4M
Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseasesU01HL175451 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BRIGITTE N GOMPERTS, Darrell N. Kotton · 2024 to 2026
$2.4M
Validation of an in vitro model of progressive fibrosis that mimics Idiopathic Pulmonary FibrosisU01HL153000 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BELPERIO, JOHN A, DAMOISEAUX, ROBERT · 2021 to 2024
$2.4M
Generation of functional lung stem cells from human iPSCsU01HL148692 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Finn Hawkins, Darrell N. Kotton · 2019 to 2026
$2.0M
Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosisK08HL163494 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Konstantinos Alysandratos · 2023 to 2026
$649k
NHLBI NIH HHS K08 HL163494NHLBI NIH HHS P01 HL170952NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL119215NHLBI NIH HHS R01 HL166139NHLBI NIH HHS U01 HL148692NHLBI NIH HHS U01 HL152976NHLBI NIH HHS U01 HL153000NHLBI NIH HHS U01 HL175451NIGMS NIH HHS R35 GM119461
6 · The paper itself

Abstract

Pulmonary fibrosis (PF) can arise from mutations in alveolar epithelial type 2 (AT2) cell-specific genes, but manifests in fibrotic activation of mesenchymal cells, thus involving fibrogenic epithelial-mesenchymal crosstalk. The ligand-receptor interactions underlying the onset and early progression of PF remain poorly understood. Induced pluripotent stem cell (iPSC)-derived models are powerful tools to study respiratory diseases, yet are currently limited to reductionist single lineage epithelial models or multi-lineage systems that lack purity and lung-specificity of the mesenchyme. Here we generate a human iPSC line carrying both a lung mesenchyme-specific reporter (TBX4-LER

Identifiers

PMID41659605
PMCPMC12873841

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.