Evidence map›Paper›PMID 41659566›Full record

ArticlebioRxiv : the preprint server for biology2026

Flexibility of cell fates and functions across sex determination systems revealed by comparative single-cell analyses.

Rafael D Acemel, Boris Tezak, Vicky Wai Yee Chung, Alicia Hurtado, Scarlett Albertson, Ceri J Weber, Blanche Capel, Darío G Lupiáñez

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rafael D AcemelCentro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide/Junta de Andalucía, Sevilla, Spain.ORCID 0000-0003-4120-0140
Boris TezakDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2621-4272
Vicky Wai Yee ChungMax-Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Epigenetics and Sex Development Group, Berlin, Germany.
Alicia HurtadoCentro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide/Junta de Andalucía, Sevilla, Spain.ORCID 0000-0001-6267-704X
Scarlett AlbertsonBiology Department, Wesleyan University, Middletown, CT 06459.
Ceri J WeberDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0001-8541-0110
Blanche CapelDepartment of Cell Biology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-6587-0969
Darío G LupiáñezCentro Andaluz de Biología del Desarrollo (CABD), Consejo Superior de Investigaciones Científicas/Universidad Pablo de Olavide/Junta de Andalucía, Sevilla, Spain.ORCID 0000-0002-3165-036X

Funding

DND1 Mediates Epigenetic Reprogramming During Cell Cycle Arrest In Male Germ CellsR01HD103064 · NICHD · DUKE UNIVERSITY · PI CAPEL, BLANCHE · 2021 to 2025
$2.0M
Intravital point-scanning confocal microscopeS10RR027867 · NCRR · DUKE UNIVERSITY · PI CHILKOTI, ASHUTOSH · 2010 to 2010
$500k
NCRR NIH HHS S10 RR027867NICHD NIH HHS R01 HD103064
6 · The paper itself

Abstract

Sex determination in vertebrates can be initiated by a wide range of genetic or environmental triggers. Yet, the degree to which gonadal cell types and genetic programs are conserved remains unresolved. Here we employed single-cell transcriptomics to characterize the temperature-dependent sex determination (TSD) program in gonads from the turtle species

Identifiers

PMID41659566
PMCPMC12873935

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.