Evidence map›Paper›PMID 41659565›Full record

ArticlebioRxiv : the preprint server for biology2026

A genetically encoded ionic-stress sensor reveals protons as a sleep driver.

Zhijian Ji, Junqiang Liu, Bingying Wang, Shuaian Wei, Yanchang Bian, Wenjie Zeng, Chan-I Chung, Zhimin Ma, Jianxiu Zhang, Xiaokun Shu and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhijian JiCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Junqiang LiuCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Bingying WangCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Shuaian WeiCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Yanchang BianCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Wenjie ZengCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Chan-I ChungCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Zhimin MaCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.
Jianxiu ZhangDepartment of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.
Xiaokun ShuCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9248-7095
Dengke K MaCardiovascular Research Institute, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-5619-7485

Funding

WormBase: a core data resource for C. elegans and other nematodesU24HG002223 · NHGRI · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TIM SCHEDL, PAUL Warren STERNBERG · 2018 to 2026
$18.9M
Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermiaR35GM139618 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Dengke Ma · 2021 to 2026
$2.3M
NHGRI NIH HHS U24 HG002223NIGMS NIH HHS R35 GM139618NIH HHS P40 OD010440NIH HHS R24 OD010943
6 · The paper itself

Abstract

Dynamic ionic changes are hallmarks of physiological and behavioral state transitions, including sleep in animals. Although biosensors for specific cellular ions are widely available, real-time monitoring of overall ionic strength in living organisms remains challenging. Here, we present a genetically encoded nuclear translocation ionic sensor (GENTIS) that enables direct visualization of ionic stress

Identifiers

PMID41659565
PMCPMC12873957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.