Evidence map›Paper›PMID 41659554›Full record

ArticlebioRxiv : the preprint server for biology2026

A developmental timer coordinates organism-wide microRNA transcription.

Peipei Wu, Jing Wang, Brett Pryor, Isabella Valentino, David F Ritter, Kaiser Loel, Justin Kinney, Sevinc Ercan, Leemor Joshua-Tor, Christopher M Hammell

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Peipei WuCold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.
Jing WangCold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.
Brett PryorCold Spring Harbor Laboratory School of Biological Sciences, One Bungtown Road, Cold Spring Harbor, NY 11724.
Isabella ValentinoCold Spring Harbor Laboratory School of Biological Sciences, One Bungtown Road, Cold Spring Harbor, NY 11724.
David F RitterNew York University, 100 Washington Square East, New York, NY 10003.
Kaiser LoelSimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.
Justin KinneySimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.
Sevinc ErcanNew York University, 100 Washington Square East, New York, NY 10003.
Leemor Joshua-TorCold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.
Christopher M HammellCold Spring Harbor Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724.ORCID 0000-0002-5961-0976

Funding

A unified quantitative modeling strategy for multiplex assays of variant effectR01HG011787 · NHGRI · COLD SPRING HARBOR LABORATORY · PI JUSTIN B. KINNEY · 2022 to 2026
$4.1M
OSCILLATORY GENE EXPRESSION AND THE MAINTENANCE OF TEMPORAL PATTERNINGR01GM117406 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN · 2016 to 2025
$4.0M
Mechanisms of condensin-mediated gene regulation in C. elegansR35GM130311 · NIGMS · NEW YORK UNIVERSITY · PI Sevinc Ercan · 2019 to 2026
$3.3M
Molecular timekeeping and temporal cell fate specification in C. elegansR01GM155806 · NIGMS · COLD SPRING HARBOR LABORATORY · PI HAMMELL, CHRISTOPHER MARTIN, JOSHUA-TOR, LEEMOR · 2024 to 2025
$1.3M
NHGRI NIH HHS R01 HG011787NIGMS NIH HHS R01 GM117406NIGMS NIH HHS R01 GM155806NIGMS NIH HHS R35 GM130311
6 · The paper itself

Abstract

The development of distinct tissues must be precisely coordinated to ensure that growth and cell fate transitions occur in the correct temporal order across the organism, yet the mechanisms that coordinate these timing events remain unclear. In

Identifiers

PMID41659554
PMCPMC12879659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.