Evidence map›Paper›PMID 41659526›Full record

ArticlebioRxiv : the preprint server for biology2026

Novel GαGTP Sensors Reveal Endogenous and Subcellular G Protein Signaling Dynamics.

Dhanushan Wijayaratna, Senuri Piyawardana, Ajith Karunarathne

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dhanushan WijayaratnaDepartment of Chemistry, Saint Louis University, Saint Louis, MO 63103.ORCID 0009-0007-6568-9530
Senuri PiyawardanaDepartment of Chemistry, Saint Louis University, Saint Louis, MO 63103.
Ajith KarunarathneDepartment of Chemistry, Saint Louis University, Saint Louis, MO 63103.ORCID 0000-0003-3136-2015

Funding

Optical control of G protein-coupled receptor functionR35GM156270 · NIGMS · SAINT LOUIS UNIVERSITY · PI Welivitiya Kankanamlage Ajith Karunarathne · 2025 to 2026
$833k
NIGMS NIH HHS R35 GM156270
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) perceive spatially and temporally diverse stimuli and activate G protein heterotrimers comprising α, β, and γ subunits, which broadcast signals through a broad range of effectors at various subcellular compartments. Therefore, understanding endogenous G protein activity dynamics at the subcellular level, thereby recapitulating

Indexed as

GPCRG proteinsMembrane-targetingSensorsSignaling AdaptationSubcellular

Identifiers

PMID41659526
PMCPMC12873897

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.