Evidence map›Paper›PMID 41659520›Full record

ArticlebioRxiv : the preprint server for biology2026

Chemo-omic pipeline enables discovery of prion synaptotoxic pathways and inhibitory drugs.

Nhat T T Le, Robert C C Mercer, Cheng Fang, Aravind Sundaravadivelu, Adam T Labadorf, Weiwei Lin, Julian Kwan, Benjamin Blum, Andrew Emili, David A Harris

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Nhat T T LeDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0003-0528-8114
Robert C C MercerDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-6029-511X
Cheng FangDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Aravind SundaravadiveluDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0009-0001-9437-3937
Adam T LabadorfBioinformatics Program, Boston University, Boston, MA 02215, USA.ORCID 0000-0002-0753-8992
Weiwei LinDepartment of Pharmacology, Physiology & Biophysics, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Julian KwanDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Benjamin BlumDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.
Andrew EmiliDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0001-8995-246X
David A HarrisDepartment of Biochemistry & Cell Biology, Boston University Chobanian & Avedisian School of Medicine, Boston, MA 02118, USA.ORCID 0000-0002-6985-5790

Funding

Zoonotic potential of CWD and influence of environmental contamination on prion propagationP01AI077774 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CLAUDIO SOTO · 2008 to 2026
$36.1M
Mechanisms of Prion Protein ToxicityR01NS065244 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2010 to 2025
$8.9M
Systems-level functional proteomics analysis assemblies in Alzheimer's disease and mouse models of tauopathyRF1AG061706 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI EMILI, ANDREW, WOLOZIN, BENJAMIN L · 2019 to 2019
$3.9M
Genetic Modifiers of Protein Interaction Networks in TauopathyR01AG064932 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI EMILI, ANDREW, WOLOZIN, BENJAMIN L · 2019 to 2023
$3.2M
Genomic and Proteomic Analysis of Prion SynaptotoxicityR21NS107755 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2018 to 2019
$454k
Identification of Anti-Prion Drug TargetsR21NS101659 · NINDS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HARRIS, DAVID A · 2017 to 2018
$453k
NIAID NIH HHS P01 AI077774NIA NIH HHS R01 AG064932NIA NIH HHS RF1 AG061706NINDS NIH HHS R01 NS065244NINDS NIH HHS R21 NS101659NINDS NIH HHS R21 NS107755
6 · The paper itself

Abstract

Prion propagation, in which the cellular prion protein (PrP

Identifiers

PMID41659520
PMCPMC12873866

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.