ArticlebioRxiv : the preprint server for biology2026
Bacterial extracellular vesicles indirectly destabilize a human stem cell-derived blood-brain barrier on-chip through pro-inflammatory stimulation of immune cells.
Louis P Widom, Panteha Torabian, Michelle A Trempel, Molly C McCloskey, Lea V Michel, James L McGrath, Thomas R Gaborski
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Louis P WidomDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, New York, United States.ORCID 0000-0002-2492-9004 Panteha TorabianDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, New York, United States.
Michelle A TrempelDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, United States.
Molly C McCloskeyDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, United States.
Lea V MichelSchool of Chemistry and Materials Science, Rochester Institute of Technology, Rochester, New York, United States.
James L McGrathDepartment of Biomedical Engineering, University of Rochester, Rochester, New York, United States.
Thomas R GaborskiDepartment of Biomedical Engineering, Rochester Institute of Technology, Rochester, New York, United States.ORCID 0000-0002-3676-3208 Funding
MPS Resources SectionU2CAG088071 · NIA · UNIVERSITY OF ROCHESTER · PI James L McGrath · 2024 to 2026
$5.9MThe µSiM-hNVU - a human BBB platform for the study of brain injury mechanisms during systemic infectionR33HL154249 · NHLBI · UNIVERSITY OF ROCHESTER · PI ENGELHARDT, BRITTA, GABORSKI, THOMAS R · 2022 to 2024
$2.2MEngineering Cell-Substrate Interactions on Porous Membranes to Create Physiologically Relevant Model SystemsR35GM153461 · NIGMS · ROCHESTER INSTITUTE OF TECHNOLOGY · PI THOMAS R GABORSKI · 2024 to 2026
$1.1MUsing nanopocket membranes to capture bacterial outer membrane vesicles from biofluidsR21AI163782 · NIAID · ROCHESTER INSTITUTE OF TECHNOLOGY · PI GABORSKI, THOMAS R, MICHEL, LEA VACCA · 2021 to 2022
$417kNHLBI NIH HHS R33 HL154249NIAID NIH HHS R21 AI163782NIA NIH HHS U2C AG088071NIGMS NIH HHS R35 GM153461
6 · The paper itselfAbstract
Pathogenic bacterial extracellular vesicles (BEVs) can disrupt the blood-brain barrier (BBB), leading to neuroinflammation. Prior
Indexed as
Bacterial extracellular vesicles (BEVs)Blood–brain barrier (BBB)brain microvascular endothelial cells (BMECs)Escherichia coliintercellular adhesion molecule-1 (ICAM-1)lab-on-chipmacrophages
Identifiers
PMID41659517
PMCPMC12873983
What OpenQuestion holds
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