Evidence map›Paper›PMID 41659510›Full record

ArticlebioRxiv : the preprint server for biology2026

Dual roles for influenza A protein PA-X: limiting inflammatory response and disrupting MHC I antigen presentation in human respiratory epithelium.

Alessandra C Setaro, Corinne Thomas, Marta M Gaglia

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alessandra C SetaroProgram in Immunology, Tufts Graduate School of Biomedical Sciences, Boston, MA.
Corinne ThomasInstitute for Molecular Virology and Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, WI.
Marta M GagliaInstitute for Molecular Virology and Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, WI.ORCID 0000-0002-1791-0663

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
NIAID Centers of Excellence for Influenza Research and Response: Universal Influenza Vaccine Research Activities75N93021C00017 · NIAID · EMORY UNIVERSITY · PI LOWEN, ANICE · 2021 to 2025
$27.3M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
Molecular Mechanism of Action of the Influenza PA-X Host Shutoff ProteinR01AI137358 · NIAID · TUFTS UNIVERSITY BOSTON · PI GAGLIA, MARTA MARIA · 2018 to 2022
$2.0M
BD FACSymphony High Parameter Flow CytometerS10OD025225 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI PATANKAR, MANISH S · 2018 to 2018
$600k
NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NIAID NIH HHS 75N93021C00017NIAID NIH HHS R01 AI137358NIH HHS S10 OD025225
6 · The paper itself

Abstract

Key to the success of influenza A virus as a pathogen are its numerous tactics of immune evasion. To suppress anti-viral cellular and organismal responses, influenza A virus encodes several immunomodulatory proteins, including the endoribonuclease PA-X. PA-X decreases inflammation and immune responses in

Identifiers

PMID41659510
PMCPMC12874031

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.