Evidence map›Paper›PMID 41659507›Full record

ArticlebioRxiv : the preprint server for biology2026

Profiling Allogeneic HLA-specific B-cell Responses Utilizing a 64-plex Single-HLA Reporter Cell Panel.

Shengli Song, Emma F King, Ashley M Drabik, Jean Kwun, Cliburn Chan, Annette M Jackson, Garnett Kelsoe, Stuart J Knechtle

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengli SongDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-0507-5194
Emma F KingDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0009-0008-2847-3519
Ashley M DrabikDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0009-0005-7305-9956
Jean KwunDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-8563-5472
Cliburn ChanDepartment of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0001-5901-6806
Annette M JacksonDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0003-2648-2944
Garnett KelsoeDepartment of Surgery, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-8770-040X
Stuart J KnechtleDuke Transplant Center, Duke University School of Medicine, Durham, NC 27710, USA.ORCID 0000-0002-1625-385X

Funding

Targeting the B Cell Response to Treat Antibody-Mediated RejectionU01AI163065 · NIAID · DUKE UNIVERSITY · PI Stuart Johnston Knechtle · 2021 to 2026
$11.8M
NIAID NIH HHS U01 AI163065
6 · The paper itself

Abstract

Identifying allogeneic HLA-specific B cells in sensitized individuals is essential for defining the cellular basis of allogeneic humoral immunity but remains technically challenging due to their low frequency. To overcome this barrier, we generated a 64-plex single-HLA reporter cell (HLA64-RC) panel that provides a cost-efficient, multiplex, high-throughput platform for screening B-cell specificity. We additionally developed a companion R package,

Identifiers

PMID41659507
PMCPMC12879672

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.