Evidence map›Paper›PMID 41659499›Full record

ArticlebioRxiv : the preprint server for biology2026

Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation.

Rebekah L Mokry, Caleb B de Lacy, John G Purdy

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Rebekah L MokryBIO5 Institute, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0002-8882-4332
Caleb B de LacyDepartment of Immunobiology, University of Arizona, Tucson, Arizona, USA.ORCID 0009-0004-0255-0708
John G PurdyBIO5 Institute, University of Arizona, Tucson, Arizona, USA.ORCID 0000-0001-7460-7567

Funding

Metabolite-mediated Signaling in Cell-to-Cell Spread of Human CytomegalovirusR01AI155539 · NIAID · UNIVERSITY OF ARIZONA · PI PURDY, JOHN GERARD · 2021 to 2025
$1.8M
Mechanisms of Human Cytomegalovirus Reprogramming of Lipid MetabolismR01AI162671 · NIAID · UNIVERSITY OF ARIZONA · PI PURDY, JOHN GERARD · 2021 to 2025
$1.8M
Impact of diverse nutrient environment on viral replication and metabolite flow in human cytomegalovirus infectionF32AI178919 · NIAID · UNIVERSITY OF ARIZONA · PI MOKRY, REBEKAH L · 2023 to 2024
$143k
NIAID NIH HHS F32 AI178919NIAID NIH HHS R01 AI155539NIAID NIH HHS R01 AI162671
6 · The paper itself

Abstract

Lipidome remodeling during human cytomegalovirus (HCMV) replication is a complex process that requires induction of lipogenic proteins and altered metabolite flow to support synthesis of fatty acids and lipids. HCMV infection increases the utilization of glucose and acetate to provide enough carbons to support increased demand for lipogenesis during virus replication, but other carbon contributors have not been studied. Here, we identify glutamine as a carbon source for lipogenesis during HCMV infection. Metabolic tracing with

Identifiers

PMID41659499
PMCPMC12873872

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.