Evidence map›Paper›PMID 41659476›Full record

ArticlebioRxiv : the preprint server for biology2026

Gabriel Grullon, Jarod Rollins, Lauren Wilkes, Aamir Zuberi, Aravinda Chakravarti, Sumantra Chatterjee

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel GrullonCenter for Human Genetics & Genomics, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0009-0002-4842-5238
Jarod RollinsTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME 04609.ORCID 0000-0002-6279-7831
Lauren WilkesCenter for Human Genetics & Genomics, New York University Grossman School of Medicine, New York, NY 10016.
Aamir ZuberiTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME 04609.
Aravinda ChakravartiCenter for Human Genetics & Genomics, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-4264-2285
Sumantra ChatterjeeCenter for Human Genetics & Genomics, New York University Grossman School of Medicine, New York, NY 10016.ORCID 0000-0002-5076-1698

Funding

Genetic Analysis of Hirschsprung Disease - RenewalR01HD028088 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAKRAVARTI, ARAVINDA · 1991 to 2024
$6.2M
Genetic Analysis of Hirschsprung DiseaseR37HD028088 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2010 to 2019
$6.2M
Why do Down Syndrome patients have high risk of Hirschsprung disease?R01DK135089 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI, Sumantra Chatterjee · 2022 to 2026
$4.2M
Computational identification of Hirschsprung disease susceptibility genesR03HD116004 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHATTERJEE, SUMANTRA · 2024 to 2024
$339k
NICHD NIH HHS R01 HD028088NICHD NIH HHS R03 HD116004NICHD NIH HHS R37 HD028088NIDDK NIH HHS R01 DK135089
6 · The paper itself

Abstract

Down syndrome (DS; trisomy 21) confers a ~100-fold increased risk of Hirschsprung disease (HSCR), yet the causal contributions of specific chromosome 21 genes remain unresolved. Here we show that increased dosage of SOD1 alone is sufficient to perturb enteric nervous system (ENS) development. We engineered a humanized

Identifiers

PMID41659476
PMCPMC12873795

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.