Evidence map›Paper›PMID 41659459›Full record

ArticlebioRxiv : the preprint server for biology2026

Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells.

Se-Jin Kim, Dylan Kain, Deborah A Lewinsohn, Gwendolyn M Swarbrick, Meghan E Cansler, Benjamin N Bimber, G W McElfresh, Emily B Wong, Sharon Khuzwayo, Thomas Riffelmacher and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Se-Jin KimDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.ORCID 0000-0002-6704-4644
Dylan KainDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Deborah A LewinsohnDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Gwendolyn M SwarbrickDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Meghan E CanslerDivision of Infectious Diseases, Department of Pediatrics, Oregon Health & Science University, Portland, OR, USA.
Benjamin N BimberOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
G W McElfreshOregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.
Emily B WongDepartment of Basic and Translational Science, Africa Health Research Institute, Durban, South Africa.
Sharon KhuzwayoCape Town HVTN Immunology Laboratory, Cape Town, South Africa.
Thomas RiffelmacherDepartment of Internal Medicine Clinic III, University of Cologne, Cologne, Germany.
David M LewinsohnDepartment of Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, OR, USA.

Funding

IMMUNE MECHANISMS OF PROTECTION AGAINST MYCOBACTERIUM TUBERCULOSIS CENTER (IMPAC-TB) - SARS-CoV-2 RELATED RESEARCH75N93019C00070 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI URDAHL, KEVIN · 2019 to 2025
$86.6M
Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Multidisciplinary Research Training in Pulmonary MedicineT32HL083808 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., SLATORE, CHRISTOPHER G. · 2008 to 2025
$5.3M
Memory, Phenotype, and Function of TB-reactive Human MR1 Restricted T cellsR01AI129980 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI LEWINSOHN, DAVID M., LEWINSOHN, DEBORAH A. · 2019 to 2022
$2.4M
High Performance Computing and Machine Learning Infrastructure for Oregon Life SciencesS10OD034224 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLROTT, KYLE · 2023 to 2023
$2.0M
BLRD VA I01 BX000533NCATS NIH HHS UL1 TR002369NHLBI NIH HHS T32 HL083808NIAID NIH HHS 75N93019C00070NIAID NIH HHS R01 AI129980NIH HHS S10 OD034224
6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are donor unrestricted T cells capable of both antigen-specific adaptive responses and cytokine driven innate-like functions. Although human MAIT cells uniformly express

Identifiers

PMID41659459
PMCPMC12873819

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.