ArticlebioRxiv : the preprint server for biology2026
Pathological TDP-43 filaments accumulate at synapses and cause synaptic dysfunction.
Renren Chen, Imogen Stockwell, Jessica C Pierce, Sew-Yeu Peak-Chew, Melissa Huang, Kathy Newell, Bernardino Ghetti, Michael A Cousin, Ingo H Greger, Benjamin Ryskeldi-Falcon
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Renren ChenMRC Laboratory of Molecular Biology, Cambridge, UK.
Imogen StockwellMRC Laboratory of Molecular Biology, Cambridge, UK.
Jessica C PierceInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.
Sew-Yeu Peak-ChewMRC Laboratory of Molecular Biology, Cambridge, UK.
Kathy NewellDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Bernardino GhettiDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, USA.
Michael A CousinInstitute for Neuroscience and Cardiovascular Research, University of Edinburgh, Edinburgh, UK.
Ingo H GregerMRC Laboratory of Molecular Biology, Cambridge, UK.
Funding
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MInvestigating the role of TDP-43 mislocalization, structure, and post-translational modifications in the neuropathologically heterogeneous TDP-43 proteinopathiesR01NS137469 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Laura Cracco, Kathy L Newell · 2024 to 2026
$3.0MIdentification of novel four repeat tauopathies through analysis of network vulnerability, tau structure and propagation.R01AG080001 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, RUBEN VIDAL · 2023 to 2026
$2.7MStructural analysis of tau associated with parenchymal and vascular prion protein amyloidosisRF1AG071177 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI GHETTI, BERNARDINO FRANCESCO, JIANG, WEN · 2021 to 2021
$2.3MStructure of amyloid fibrils in human neurodegenerative diseases and agingR01NS110437 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI BERNARDINO Francesco GHETTI, Wen Jiang · 2026 to 2026
$1.2MNIA NIH HHS P30 AG010133NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG080001NIA NIH HHS RF1 AG071177NINDS NIH HHS R01 NS110437NINDS NIH HHS R01 NS137469
6 · The paper itselfAbstract
The assembly of TAR DNA-binding protein 43 (TDP-43) into amyloid filaments within neurons is a hallmark of multiple neurodegenerative diseases, including motor neuron diseases (MND), frontotemporal dementias (FTD) and limbic-predominant age-related TDP-43 encephalopathy (LATE). These diseases result from the deterioration and loss of neurons, with synaptic dysfunction and neuronal hyperexcitability being prominent early events. Pathogenic mutations in the TDP-43 gene,
Indexed as
ALSamyloidcryo-ETFTDFTLD-TDPNeurodegenerationprion-like propagationprotein aggregationproximity labelling proteomicssynapseTDP-43
Identifiers
PMID41659424
PMCPMC12873875
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