ArticlebioRxiv : the preprint server for biology2026
Toward identification of common DNA repair process in mutational signatures.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mutational signatures are characteristic patterns of mutation frequencies assumed to be generated by specific mutagenic processes. A growing catalog of mutational signatures exists, but tools to systematically infer relationships between them remain limited. A mutational signature can be viewed as the combined outcome of two processes: DNA damage and DNA repair. Since cancer therapies often target DNA repair, inferring DNA repair pathways is important for treatment design, even when the mutagenic process is unknown. Here, we model the DNA repair step as a transformation, called RePrint, from damaged nucleotides to repair-related mutation patterns conditioned on the damage. We demonstrate that RePrint similarity is indicative of shared DNA repair mechanisms, enabling
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