Evidence map›Paper›PMID 41659394›Full record

ArticlebioRxiv : the preprint server for biology2026

The isolated

Tucker Shriver, Sandra Berndt, Scott A Robson, Austin D Dixon, Ines Liebscher, Joshua J Ziarek

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Tucker ShriverDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0009-0001-5121-8881
Sandra BerndtRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Saxony, Germany.ORCID 0000-0002-9732-9413
Scott A RobsonDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-0529-0399
Austin D DixonBiologics Discovery Sciences - Biologics Production, AbbVie, Chicago, Illinois, USA.ORCID 0000-0001-8676-915X
Ines LiebscherRudolf Schönheimer Institute of Biochemistry, Medical Faculty, Leipzig University, Leipzig, Saxony, Germany.ORCID 0000-0003-4480-8987
Joshua J ZiarekDepartment of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.ORCID 0000-0002-3740-9999

Funding

INTEGRATIVE PREDOCTORAL TRAINING IN DRUG ABUSE RESEARCH AT INDIANA UNIVERSITYT32DA024628 · NIDA · TRUSTEES OF INDIANA UNIVERSITY · PI Andrea Grace Hohmann, Kenneth Mackie · 2008 to 2026
$3.1M
Molecular Biophysics Training Program at Northwestern UniversityT32GM140995 · NIGMS · NORTHWESTERN UNIVERSITY · PI Heather Wendy Pinkett, Reza Vafabakhsh · 2021 to 2026
$2.5M
The role of dynamics in GPCR and arrestin allosteryR35GM143054 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI ZIAREK, JOSHUA JAMES · 2021 to 2025
$2.1M
Entropic Redistribution Drives the GRK-Independent Binding of Arrestin 2 to the Cannabinoid 2 ReceptorF31DA060484 · NIDA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHRIVER, THOMAS · 2024 to 2025
$99k
NIDA NIH HHS F31 DA060484NIDA NIH HHS T32 DA024628NIGMS NIH HHS R35 GM143054NIGMS NIH HHS T32 GM140995
6 · The paper itself

Abstract

Several members of the adhesion subfamily of G protein-coupled receptors (aGPCRs) are capable of self-activation by an internal agonist sequence (aka the

Indexed as

ADGRG6adhesion GPCRsdisordereddisorder-to-order transitionligandorder-to-disorder transitionpeptide NMRstructure

Identifiers

PMID41659394
PMCPMC12879654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.