ArticleAlzheimer's & dementia (New York, N. Y.)
Lower CD8+ T-cell senescence partially mediates the neuroprotection of higher aerobic fitness.
Article in Alzheimer's & dementia (New York, N. Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Peripheral TARC (CCL17) Levels Track Widespread Microstructural Vulnerability in Cognitively Unimpaired Older African Americans.medRxiv : the preprint server for health sciences · 2026Article
- Lower CD8+ T-cell senescence partially mediates the neuroprotection of higher aerobic fitness.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
16 authors.
Funding
Abstract
introductionImmunosenescence - age-related changes in immunity - may exacerbate the pathologic processes of Alzheimer's disease (AD), a condition that disproportionately affects African Americans. Fortunately, a higher level of aerobic fitness is linked to both reduced immunosenescence and lower AD risk. However, it remains unclear whether higher aerobic fitness and decreased AD is mediated by lower proportions of T-cell senescence. In a cohort of older African Americans, we aimed to (1) examine the relationship between aerobic fitness and generalization (a cognitive indicator of AD risk) and (2) investigate whether T-cell senescence mediated this relationship.
methodsA total of 231 older African American participants from the Aging & Brain Health Alliance (
resultsHigher aerobic fitness was significantly associated with fewer generalization errors. Furthermore, higher aerobic fitness was associated with lower CD8+ T-cell senescence ( DISCUSSION: One pathway by which higher aerobic fitness is associated with lower AD risk in older African Americans is through lower proportions of CD8+ T-cell senescence. These results highlight the immune and cognitive function benefits of a physically active lifestyle, particularly in a demographic that faces a higher risk for AD.
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