ArticleNanoscale advances2026
An enzymatic microfluidic sensor for β-lactam antibiotics based on cross-linked ancestral β-lactamase crystals.
Article in Nanoscale advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A microfluidic enzymatic sensor based on cross-linked crystals of an ancestral β-lactamase (βLa-CLECs) was developed for the detection of β-lactam antibiotics under continuous flow conditions. The sensor is presented in a modular configuration, consisting of a separated microprobe for enzymatic catalysis, allowing for precise enzyme loading, and a photonic lab-on-a-chip (PhLoC) platform for detection by in-line spectrophotometric measurements. The exceptional thermal stability of the reconstructed Precambrian β-lactamase made it suitable for the steps required in device fabrication and carrier-free immobilization treatment, while its inherent promiscuity,
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