ArticleFrontiers in endocrinology2025
Association between sleep apnea-specific novel hypoxic metrics and disturbances in glucose and lipid metabolism.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Obstructive sleep apnea (OSA) has been linked to disturbances in glucose and lipid metabolism. The independent association between sleep apnea-specific novel hypoxic metrics and metabolic dysregulation in OSA, however, remains unclear. Methods: Anthropometric and polysomnographic data were obtained from OSA patients treated. Novel hypoxic indices-percentage of sleep time with the duration of respiratory events causing desaturation (pRED_3p) and sleep breathing impairment index (SBII)-were derived from the SpO Results: After controlling for confounding variables, pRED_3p demonstrated significant associations with fasting blood glucose (FBG) (β=0.122), fasting insulin (FIN) (β=0.410), HOMA-IR (β=0.325), total cholesterol (TC) (β=0.309), triglycerides (TG) (β=0.173), low-density lipoprotein cholesterol (LDL-C) (β=0.260), TC/HDL-C (β=0.182), TG/HDL-C (β=0.121), LDL-C/HDL-C (β=0.195), AI (β=0.182), LCI (β=0.663), visceral adiposity index (VAI) (β=0.115), and lipid accumulation product (LAP) (β=0.139). SBII was independently related to FBG (β=0.079), FIN (β=0.240), HOMA-IR (β=0.191), TC (β=0.179), TG (β=0.115), LDL-C (β=0.139), LDL-C/HDL-C (β=0.081), LCI (β=0.093), and LAP (β=0.098), all with Conclusion: pRED_3p and SBII were associated not only with established glucose and lipid metabolism parameters-including elevated FBG, FIN, HOMA-IR, hypercholesterolemia, hypertriglyceridemia, and elevated LDL-C-but also with composite lipid indices, exhibiting consistent linear trends. Greater OSA severity corresponded to more marked disturbances in glucose and lipid metabolism. These novel hypoxic metrics may serve as predictive indicators for metabolic dysregulation in OSA.
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