ArticleRSC advances2026
Nitric oxide-releasing hyaluronic acid as an antibacterial and immunomodulatory acne therapeutic.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Metal oxide nanoparticles for acne vulgaris: mechanisms, synthesis, formulation, and translational prospects.RSC advances · 2026Review
- Blue Light-Mediated Nitric Oxide-Releasing Formulation for the Multimodal Treatment of Acne Vulgaris.Advanced healthcare materials · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris (acne) is a common skin disorder associated with significant psychosocial impact. Current clinical therapies include topical and systemic antibiotics, benzoyl peroxide, and retinoids. While moderately effective, these clinical therapies fail to target all four major pathogenic causes of acne and are associated with painful side effects. Nitric oxide (NO), an endogenous signaling molecule, represents a promising alternative to conventional acne treatments due to its innate antibacterial and immunomodulatory functions. As NO is highly reactive, macromolecular NO donors are required for its controlled, solution-phase delivery. Prior work has utilized silica nanoparticle scaffolds to store and deliver NO, with the silica scaffold being considered inert. Herein, NO-releasing hyaluronic acid (HA), an endogenously produced biopolymer, was modified with NO donors to enable a dual-action therapeutic capable of addressing the pathogenic factors responsible for acne development. The molecular weight of these HA derivatives proved important with respect to bactericidal activity against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.